Fig. 1 · Structure
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Integrase-LEDGF/p75 allosteric inhibitor 1
IN-LEDGF/p75 Inhibitor
Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is a potent allosteric inhibitor targeting the integrase-LEDGF/p75 interaction. It effectively inhibits HIV-1 DNA integration, demonstrating significant antiviral activity with an EC50 of 3.9 nM against the HIV-1 recombinant molecular clone NL432. This compound is useful for research applications focused on HIV-1 therapeutics and understanding the mechanisms of viral replication and integration.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1431738-14-5 |
| Applications | IN-LEDGF/p75 Inhibitor |
| Formula | C33H41NO6S |
| Molecular Weight | 579.75 |
| SMILES | CC1=CC=C(C=C1C)C2=C(C(C3=CC=C4OCCCC4=C3C)=C(C(C)=C2NS(C)(=O)=O)C(C(O)=O)OC(C)(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.