Fig. 1 · Structure
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IR-1048
NTR Probe
IR-1048 is a nitroreductase (NTR)-responsive near-infrared (NIR) fluorescence and photoacoustic imaging probe, as well as a photothermal agent. This compound features a nitroimidazole group, which upon catalytic reduction by NTR in hypoxic conditions, re-establishes strong NIR absorption and fluorescence emission in the NIR II window. The resulting photothermal effect allows for targeted imaging and photothermal ablation of tumor hypoxic regions. IR-1048 is primarily utilized in high-contrast NIR II/photoacoustic imaging and photothermal therapy research, focusing on the characterization and diagnosis of the tumor hypoxic microenvironment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 155613-98-2 |
| Applications | NTR Probe |
| Formula | C40H38BCl3F4N2 |
| Molecular Weight | 739.91 |
| Synonyms | S01448 |
| SMILES | [F-][B+3]([F-])([F-])[F-].ClC1=CC=C2C3=C(/C(N2CCCC)=C\C=C4C(Cl)=C(CCC\4)/C=C/C5=[N+](CCCC)C6=CC=C(Cl)C7=CC=CC5=C67)C=CC=C31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.