Fig. 1 · Structure
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Isethionic acid (80% in water)
Calcium Binder
Isethionic acid is a calcium binder that functions by competitively occupying calcium binding sites on the outer mitochondrial membrane, thereby enhancing mitochondrial calcium binding capacity. This compound inhibits calcium-activated mitochondrial respiration and demonstrates significant biological activity by affecting barnacle (Balanus amphitrite) larvae with LC50 values of 23 µg/mL at 24 hours and 17 µg/mL at 48 hours. Isethionic acid effectively prevents the attachment of barnacle larvae at concentrations as low as 10 µg/mL and regulates mitochondrial calcium transport, promoting ATP-dependent calcium uptake in high calcium environments. This reagent is valuable for investigations into mitochondrial calcium metabolism mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 107-36-8 |
| Applications | Calcium Binder |
| Formula | C2H6O4S |
| Molecular Weight | 126.13 |
| Synonyms | 2-Hydroxyethanesulfonic acid |
| SMILES | O=S(CCO)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.