Isosilybin B is a flavonolignan with significant anticancer activity primarily targeting prostate cancer. Isolated from Silybum marianum, it regulates cell cycle-related proteins by downregulating cyclins D3, D1, A, and E, as well as Cdk4, Cdk2, and Cdc25A. Additionally, Isosilybin B activates Caspases 9 and 3, promoting apoptosis and reducing levels of the androgen receptor (AR) and prostate-specific antigen (PSA). This compound is valuable for research focused on cancer biology and therapeutic interventions.
Isosilybin B is a flavonolignan with significant anticancer activity primarily targeting prostate cancer. Isolated from Silybum marianum, it regulates cell cycle-related proteins by downregulating cyclins D3, D1, A, and E, as well as Cdk4, Cdk2, and Cdc25A. Additionally, Isosilybin B activates Caspases 9 and 3, promoting apoptosis and reducing levels of the androgen receptor (AR) and prostate-specific antigen (PSA). This compound is valuable for research focused on cancer biology and therapeutic interventions.
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