Tigilanol tiglate is a natural compound that activates protein kinase C (PKC) and C1 domains, leading to mitochondrial and endoplasmic reticulum dysfunction. This dysregulation triggers the unfolded protein response (UPR), resulting in ATP depletion, organelle expansion, and the activation of apoptotic pathways including Caspase activation and gasdermin E cleavage, ultimately driving terminal necrosis. Due to its anti-tumor and immunomodulatory properties, tigilanol tiglate is valuable for research on head and neck squamous cell carcinoma and soft tissue sarcoma.
Tigilanol tiglate is a natural compound that activates protein kinase C (PKC) and C1 domains, leading to mitochondrial and endoplasmic reticulum dysfunction. This dysregulation triggers the unfolded protein response (UPR), resulting in ATP depletion, organelle expansion, and the activation of apoptotic pathways including Caspase activation and gasdermin E cleavage, ultimately driving terminal necrosis. Due to its anti-tumor and immunomodulatory properties, tigilanol tiglate is valuable for research on head and neck squamous cell carcinoma and soft tissue sarcoma.
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