Catalog No.: A14302

PERK inhibitor


ISRIB Chemical Structure

CAS NO. 1597403-47-8

ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis, Proc Natl Acad Sci U S A, 2021, May 18;118(20) PMID: 33972447
  • Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB prevents pulmonary fibrosis, bioRxiv, 2020, February 27

Biological Activity

ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
5 nM
In vitro DMSO 4 mg/mL (8.86 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.16 mL 110.78 mL 221.56 mL
0.5 mM 4.43 mL 22.16 mL 44.31 mL
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL

*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14302
Actions Inhibitor
CAS No. 1597403-47-8
Formula C22H24Cl2N2O4
M. Wt 451.34
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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