ISRIB

Catalog No.: A14302
PERK inhibitor
ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
Grouped product items
Product Name Price Stock Qty
ISRIB 10mg
$100.00
In stock
ISRIB 25mg
$200.00
In stock
ISRIB 50mg
$350.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's ISRIB has been cited by 3 publications
  • Zhou W, .et al. , Research Square, 2023, MAY 03
  • Satoshi Watanabe, .et al. , Proc Natl Acad Sci U S A, 2021, May 18;118(20) PMID: 33972447
  • Satoshi Watanabe, .et al. , bioRxiv, 2020, February 27
  • Biological Activity
    Discription ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
    Targets
    Target Value
    Product Information
    Catalog Num A14302
    Formula C22H24Cl2N2O4
    Molecular Weight 451.34
    CAS Number 1597403-47-8
    SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 4 mg/mL (8.86 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.16 mL 110.78 mL 221.56 mL
    0.5 mM 4.43 mL 22.16 mL 44.31 mL
    1 mM 2.22 mL 11.08 mL 22.16 mL
    5 mM 0.44 mL 2.22 mL 4.43 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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      C2

      V2

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