Fig. 1 · Structure
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iST2-1
ST2 Inhibitor
iST2-1 is a selective ST2 inhibitor that effectively disrupts the interaction between ST2 and IL-33, exhibiting an IC50 value of 46.65 μM. This compound acts as an immunomodulator by reducing the proliferation of CD4+ and CD8+ T cells while enhancing regulatory T cell populations, specifically increasing Foxp3+CD4+ cells in the gastrointestinal tract. iST2-1 has demonstrated the ability to lower plasma levels of soluble ST2 and IFN-γ, thereby mitigating graft-versus-host disease severity and improving survival in associated animal models. This reagent is valuable for research focused on graft-versus-host disease mechanisms and therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1019158-02-1 |
| Applications | ST2 Inhibitor |
| Formula | C22H22N2O4 |
| Molecular Weight | 378.42 |
| SMILES | COC1=CC=C(C=C1)C1CCCN1CC1=CC=C(O1)C1=CC=CC=C1[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.