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ITA-5

TBK1 Inhibitor

ITA-5 is a potent inhibitor of TBK1, derived from itaconic acid. It effectively reduces the phosphorylation of TBK1, IRF3, and STAT1, significantly inhibiting the secretion of IFN-β. This compound is valuable for investigations into autoimmune diseases and the modulation of excessive inflammation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2374162-36-2
Applications	TBK1 Inhibitor
Formula	C₁₆H₁₉NO₅
Molecular Weight	305.33
SMILES	C=C(C(N[C@H](C(OC)=O)CC1=CC=CC=C1)=O)CC(OC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.