Itaconate-alkyne is a bioorthogonal probe designed for quantitative and site-specific chemoproteomic profiling of itaconation in live cells. As a functional analogue of itaconate, it exhibits comparable anti-inflammatory effects while facilitating the labeling of itaconate's genuine biological targets. This reagent incorporates an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it a valuable tool for studying metabolic processes and inflammatory responses.
Itaconate-alkyne is a bioorthogonal probe designed for quantitative and site-specific chemoproteomic profiling of itaconation in live cells. As a functional analogue of itaconate, it exhibits comparable anti-inflammatory effects while facilitating the labeling of itaconate's genuine biological targets. This reagent incorporates an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it a valuable tool for studying metabolic processes and inflammatory responses.
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