Fig. 1 · Structure
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IU1-248
USP14 Inhibitor
IU1-248 is a potent and selective inhibitor of the deubiquitinating enzyme USP14, exhibiting an IC50 of 0.83 μM. By inhibiting USP14, this compound plays a critical role in the modulation of protein degradation pathways, influencing cellular processes such as protein homeostasis and stress response. IU1-248 is valuable for research applications investigating ubiquitin-proteasome system dynamics and potential therapeutic strategies for diseases linked to protein misfolding and degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2307472-03-1 |
| Applications | USP14 Inhibitor |
| Formula | C20H23N3O2 |
| Molecular Weight | 337.42 |
| SMILES | N#CC1=CC=C(N2C(C)=C(C(CN3CCC(O)CC3)=O)C=C2C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.