Fig. 1 · Structure
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Izilendustat hydrochloride
Prolyl Hydroxylase Inhibitor
Izilendustat hydrochloride is a potent prolyl hydroxylase inhibitor that stabilizes hypoxia-inducible factors, specifically HIF-1α and HIF-2. This compound exhibits significant biological activity by enhancing cellular responses to hypoxia, making it a valuable tool for investigating diseases related to HIF-1α, such as peripheral vascular disease, coronary artery disease, heart failure, ischemia, anemia, and inflammatory bowel diseases. Izilendustat hydrochloride is instrumental in research exploring therapeutic strategies targeting hypoxic conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1303513-80-5 |
| Applications | Prolyl Hydroxylase Inhibitor |
| Formula | C22H29Cl2N3O4 |
| Molecular Weight | 470.39 |
| SMILES | O=C(N1CCN(CC(C=CN2CC3=CC=C(Cl)C=C3)=C(O)C2=O)CC1)OC(C)(C)C.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.