Fig. 1 · Structure
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Izilendustat
Prolyl Hydroxylase Inhibitor
Izilendustat is a selective inhibitor of prolyl hydroxylase that effectively stabilizes hypoxia-inducible factors HIF-1α and HIF-2α. Its ability to enhance HIF signaling pathways makes it a valuable tool for investigating various diseases linked to immune responses, particularly in inflammatory conditions such as colitis and inflammatory bowel disease. Researchers can utilize Izilendustat to explore therapeutic strategies targeting these diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1303512-02-8 |
| Applications | Prolyl Hydroxylase Inhibitor |
| Formula | C22H28ClN3O4 |
| Molecular Weight | 433.93 |
| SMILES | O=C(N1CCN(CC(C=CN2CC3=CC=C(Cl)C=C3)=C(O)C2=O)CC1)OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.