Fig. 1 · Structure
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J-104123
Squalene Synthase Inhibitor
J-104123 is a potent inhibitor of squalene synthase, featuring a monocarboxylic acid structure. This compound has demonstrated the ability to reduce serum cholesterol levels in canine models, making it a valuable tool in cholesterol metabolism research and the study of lipid biosynthesis pathways. Its application is relevant for exploring novel therapeutic strategies for hyperlipidemia and related cardiovascular conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 162037-54-9 |
| Applications | Squalene Synthase Inhibitor |
| Formula | C28H29Cl2NO3 |
| Molecular Weight | 498.44 |
| SMILES | O=C(C[C@@H](CC(N[C@@H](C)[C@H](/C=C/C1=CC=C2C=CC=CC2=C1)CC3=CC=C(C(Cl)=C3)Cl)=O)C)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.