J 104129 fumarate is a selective muscarinic M3 antagonist, demonstrating a Ki value of 4.2 nM for M3 and 490 nM for M2, indicating a high degree of selectivity. This compound effectively antagonizes acetylcholine-induced bronchoconstriction, making it a valuable tool for investigating obstructive airway diseases. Its oral activity and specificity present opportunities for research in pulmonary pharmacology and the treatment of respiratory conditions.
J 104129 fumarate is a selective muscarinic M3 antagonist, demonstrating a Ki value of 4.2 nM for M3 and 490 nM for M2, indicating a high degree of selectivity. This compound effectively antagonizes acetylcholine-induced bronchoconstriction, making it a valuable tool for investigating obstructive airway diseases. Its oral activity and specificity present opportunities for research in pulmonary pharmacology and the treatment of respiratory conditions.
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