Fig. 1 · Structure
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J 104129 fumarate
Muscarinic M3 Antagonist
J 104129 fumarate is a selective muscarinic M3 antagonist, demonstrating a Ki value of 4.2 nM for M3 and 490 nM for M2, indicating a high degree of selectivity. This compound effectively antagonizes acetylcholine-induced bronchoconstriction, making it a valuable tool for investigating obstructive airway diseases. Its oral activity and specificity present opportunities for research in pulmonary pharmacology and the treatment of respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 257603-40-0 |
| Applications | Muscarinic M3 Antagonist |
| Formula | C28H40N2O6 |
| Molecular Weight | 500.63 |
| SMILES | O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3.OC(/C=C/C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.