Fig. 1 · Structure
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J 104871
FTase Inhibitor
J 104871 is a farnesyltransferase (FTase) inhibitor that competes with farnesyl pyrophosphate (FPP) for binding. It demonstrates potent inhibitory activity against rat brain FTase, with an IC50 value of 3.9 nM in the presence of FPP. This compound is valuable for research applications focusing on the biochemical pathways modulated by FTase, including those relevant to cancer and cardiovascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 191088-19-4 |
| Applications | FTase Inhibitor |
| Formula | C38H32N2O12 |
| Molecular Weight | 708.67 |
| Synonyms | J-104135 |
| SMILES | O=C(C1(C(O)=O)O[C@H](C(N([C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)C/C=C/C4=NC5=CC=CC=C5O4)CC6=CC=C7C=CC=CC7=C6)=O)[C@H](C(O)=O)O1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.