Fig. 1 · Structure
Documents & Downloads
J-1063
Cat. No.
A84906
CAS
2374772-46-8
ALK5 Inhibitor
J-1063 is a potent and selective inhibitor of ALK5, demonstrating an IC50 of 0.039 µM. This compound exerts anti-fibrotic effects through the inhibition of inflammatory infiltration, collagen deposition, and hepatocyte necrosis. J-1063 is valuable for research focused on liver fibrosis and associated cellular mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2374772-46-8 |
| Applications | ALK5 Inhibitor |
| Formula | C24H19N5OS |
| Molecular Weight | 425.51 |
| SMILES | CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.