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J-1149

ALK5 Inhibitor

J-1149 is a potent inhibitor of ALK5 (activin receptor-like kinase 5), exhibiting an IC50 value of 0.017 μM. Additionally, J-1149 demonstrates weak inhibitory activity against p38α MAP kinase, with an IC50 of 0.435 μM. This compound is relevant for research into liver fibrosis and related fibrotic diseases, providing a valuable tool for investigating therapeutic strategies targeting TGF-β signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2883580-95-6
Applications	ALK5 Inhibitor
Formula	C₂₅H₂₄N₈O
Molecular Weight	452.51
SMILES	N[C@H](CC1=CC=CC=C1)C(NCC2=NC(C3=CC=CC(C)=N3)=C(C4=CN5C(C=C4)=NC=N5)N2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.