JMV 449 acetate is a highly potent agonist of the neurotensin receptor. It demonstrates an IC50 of 0.15 nM in inhibiting 125I-neurotensin binding to neonatal mouse brain tissue and an EC50 of 1.9 nM in inducing contractions in the guinea-pig ileum. Additionally, JMV 449 acetate exhibits significant, long-lasting hypothermic and analgesic effects in mouse models, making it valuable for research in pain management and neuropharmacology.
JMV 449 acetate is a highly potent agonist of the neurotensin receptor. It demonstrates an IC50 of 0.15 nM in inhibiting 125I-neurotensin binding to neonatal mouse brain tissue and an EC50 of 1.9 nM in inducing contractions in the guinea-pig ileum. Additionally, JMV 449 acetate exhibits significant, long-lasting hypothermic and analgesic effects in mouse models, making it valuable for research in pain management and neuropharmacology.
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