Fig. 1 · Structure
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JNJ-37822681
Dopamine Receptor Antagonist
JNJ-37822681 is a fast-dissociating antagonist of the D2 dopamine receptor, primarily employed in the research of schizophrenia. This compound demonstrates high specificity for D2 receptors and effectively increases levels of extracellular serotonin, dopamine, and norepinephrine within the rat cerebral cortex. Additionally, JNJ-37822681 exhibits antidepressant-like effects in the mouse tail suspension test while achieving favorable brain distribution and minimizing prolactin release, making it a valuable tool for neuroscience research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 935776-74-2 |
| Applications | Dopamine Receptor Antagonist |
| Formula | C17H17F5N4 |
| Molecular Weight | 372.34 |
| SMILES | FC1=CC=C(CN2CCC(CC2)NC3=NN=C(C(F)(F)F)C=C3)C=C1F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.