Fig. 1 · Structure
Documents & Downloads
JNJ-38893777
Cat. No.
A68847
CAS
951135-00-5
TRPV1 Channel Antagonist
JNJ-38893777 is a selective antagonist of the transient receptor potential vanilloid type 1 (TRPV1) channel. By inhibiting neuronal hyperactivation, JNJ-38893777 effectively reduces inflammatory hyperalgesia, making it a valuable tool for studies focused on migraine headaches, as well as neuropathic and inflammatory pain research. Its oral activity further enhances its potential in pharmacological applications targeting pain modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 951135-00-5 |
| Applications | TRPV1 Channel Antagonist |
| Formula | C26H26F6N6 |
| Molecular Weight | 536.52 |
| SMILES | FC(C1=CC=CN=C1N2CCC3=NC(N4CCCCC4)=NC(NC5=CC=C(C(F)(F)F)C=C5)=C3CC2)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.