JNJ-39729209 is a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel, displaying pIC50 values of 7.9 to 8.5 across various species including human, rat, canine, and guinea pig. This compound effectively inhibits capsaicin-induced hypotension and associated hypothermia. Additionally, JNJ-39729209 demonstrates significant anti-inflammatory and analgesic effects in carrageenan and CFA-induced thermal hyperalgesia models in rats, as well as anti-cough activity in guinea pigs, making it a valuable tool for research in pain and inflammatory response.
JNJ-39729209 is a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel, displaying pIC50 values of 7.9 to 8.5 across various species including human, rat, canine, and guinea pig. This compound effectively inhibits capsaicin-induced hypotension and associated hypothermia. Additionally, JNJ-39729209 demonstrates significant anti-inflammatory and analgesic effects in carrageenan and CFA-induced thermal hyperalgesia models in rats, as well as anti-cough activity in guinea pigs, making it a valuable tool for research in pain and inflammatory response.
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