Fig. 1 · Structure
Documents & Downloads
JNJ-42226314
Selective MAGL Inhibitor
JNJ-42226314 is a selective and reversible inhibitor of monoacylglycerol lipase (MAGL) that operates through competitive binding. This compound effectively enhances the levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) in a dose-dependent manner. JNJ-42226314 has shown promise in preclinical models for research applications related to neuropathic and inflammatory pain, making it a valuable tool for studying cannabinoid signaling pathways and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1252765-13-1 |
| Applications | Selective MAGL Inhibitor |
| Formula | C26H24FN5O2S |
| Molecular Weight | 489.56 |
| SMILES | O=C(N1CCN(C2CN(C(C3=CC4=C(N(C5=CC=C(F)C=C5)C=C4)C=C3)=O)C2)CC1)C6=NC=CS6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.