JNJ-54175446

Catalog No.: A18675

P2X7 receptor antagonist

JNJ-54175446

JNJ-54175446 Chemical Structure

CAS NO. 1627902-21-9

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

Availability: In stock

Package Price Qty
1 mg
$480.00
5 mg
$880.00
10 mg
$1,380.00
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Biological Activity

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.69 mL 113.44 mL 226.87 mL
0.5 mM 4.54 mL 22.69 mL 45.37 mL
1 mM 2.27 mL 11.34 mL 22.69 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18675
Actions Antagonist
M. Wt 440.78
Formula C18H13ClF4N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1627902-21-9
Synonyms JNJ54175446, JNJ 54175446
SMILES ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[[email protected]]2C)=O)C(F)(F)F

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