Fig. 1 · Structure
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JNJ-61803534
Cat. No.
A77560
CAS
1917306-14-9
RORγt Inverse Agonist
JNJ-61803534 is a potent RORγt inverse agonist, exhibiting an IC50 of 9.6 nM. This compound demonstrates significant anti-inflammatory activity by inhibiting the production of IL-17A in human CD4+ T cells during Th17 differentiation. JNJ-61803534 is valuable for research in autoimmune disease and inflammation pathways, facilitating the study of RORγt as a therapeutic target.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1917306-14-9 |
| Applications | RORγt Inverse Agonist |
| Formula | C23H23Cl2F6N3O4S |
| Molecular Weight | 622.41 |
| SMILES | O=C(C1=NC(C(N2[C@H](C)CCC2)=O)=C(C3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C(Cl)=C3Cl)S1)NCC(C)(O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.