Fig. 1 · Structure
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JNT-517
SLC6A19 Inhibitor
JNT-517 is a selective allosteric inhibitor of the SLC6A19 transporter, exhibiting an IC50 value of 47 nM for human SLC6A19. This compound is primarily utilized in the research of phenylketonuria (PKU), enabling investigations into the modulation of amino acid transport and potential therapeutic strategies. Its oral bioactivity makes it a valuable tool for studying SLC6A19-related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2837993-05-0 |
| Applications | SLC6A19 Inhibitor |
| Formula | C18H22F4N4O3 |
| Molecular Weight | 418.39 |
| SMILES | FC(C=C(C=C1)OC(F)(F)F)=C1CNC(N(C2CC2)[C@H]3CN(CCC3)C(N)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.