Jobosic acid is a saturated fatty acid that functions as a selective inhibitor of SARS-CoV-2. It effectively inhibits the main protease (Mpro) and the spike receptor binding domain (RBD) interaction with ACE-2, demonstrating IC50 values of 7.5 μg/mL and 3 μg/mL, respectively. Jobosic acid also exhibits inhibitory effects on viral entry for the omicron variant of SARS-CoV-2, making it a valuable compound for research in antiviral therapies.
Jobosic acid is a saturated fatty acid that functions as a selective inhibitor of SARS-CoV-2. It effectively inhibits the main protease (Mpro) and the spike receptor binding domain (RBD) interaction with ACE-2, demonstrating IC50 values of 7.5 μg/mL and 3 μg/mL, respectively. Jobosic acid also exhibits inhibitory effects on viral entry for the omicron variant of SARS-CoV-2, making it a valuable compound for research in antiviral therapies.
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