Fig. 1 · Structure
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JT001 sodium
NLRP3 Inhibitor
JT001 sodium is a selective and orally bioavailable inhibitor of the NLRP3 inflammasome. By disrupting NLRP3 assembly, it effectively inhibits the release of pro-inflammatory cytokines and prevents pyroptosis. This compound is valuable for research into nonalcoholic steatohepatitis and liver fibrosis, providing insights into potential therapeutic strategies for these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2238820-09-0 |
| Applications | NLRP3 Inhibitor |
| Formula | C19H22N4NaO4S |
| Molecular Weight | 425.46 |
| Synonyms | NLRP3-IN-19 sodium |
| SMILES | O=C(NS(=O)(C1=C2OCCCN2N=C1)=O)NC3=C4CCCC4=CC5=C3CCC5.[Na] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.