Fig. 1 · Structure
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JZP-361
MAGL Inhibitor
JZP-361 is a potent, reversible, and selective inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 of 46 nM. This compound demonstrates antihistaminergic activity and is suitable for applications in asthma research and studies related to endocannabinoid metabolism. Its specificity for MAGL makes it a valuable tool for investigating the role of endocannabinoids in various physiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1680193-80-9 |
| Applications | MAGL Inhibitor |
| Formula | C22H20ClN5O |
| Molecular Weight | 405.88 |
| SMILES | O=C(N(CC/1)CCC1=C2C3=C(CCC4=C/2N=CC=C4)C=C(C=C3)Cl)N5N=CN=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.