K-975 is a selective and orally bioavailable TEAD inhibitor that disrupts protein-protein interactions between YAP1/TAZ and TEAD. This compound forms a covalent bond with Cys359 within the palmitate-binding pocket of TEAD through its acrylamide structure. K-975 demonstrates significant antitumor activity, particularly in the treatment of malignant pleural mesothelioma, making it a valuable tool for cancer research and therapeutic investigations targeting the YAP1/TAZ-TEAD signaling pathway.
K-975 is a selective and orally bioavailable TEAD inhibitor that disrupts protein-protein interactions between YAP1/TAZ and TEAD. This compound forms a covalent bond with Cys359 within the palmitate-binding pocket of TEAD through its acrylamide structure. K-975 demonstrates significant antitumor activity, particularly in the treatment of malignant pleural mesothelioma, making it a valuable tool for cancer research and therapeutic investigations targeting the YAP1/TAZ-TEAD signaling pathway.
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