Fig. 1 · Structure
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K103
Phosphatase
K103 is a selective inhibitor targeting SHIP1 and SHIP2 phosphatases, demonstrating significant biological activity against various cancer cell lines, particularly breast cancer. This compound achieves its anti-tumor effects through the induction of G2/M cell cycle arrest and the activation of apoptotic pathways, specifically via caspase cascade activation in multiple myeloma cells. Although K103 has been characterized as a small molecule agent, its psychoactive effects in vivo have prompted investigations into its structural modifications to enhance pharmacodynamic properties and reduce adverse side effects, while maintaining pan-SHIP1/2 inhibition. This makes K103 a valuable tool for research in cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1071544-43-8 |
| Applications | Phosphatase |
| Formula | C19H22Cl2N2S |
| Molecular Weight | 381.36 |
| SMILES | ClC1=C(CN2C3=C(C(CCN)=C2C)C=C(SC)C=C3)C=CC=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.