K11 is a stable antimicrobial peptide that exhibits significant activity against multidrug-resistant and extensively drug-resistant K. pneumoniae isolates, demonstrating a minimum inhibitory concentration (MIC) range of 8-512 μg/mL. This peptide not only inhibits bacterial biofilm formation but also displays synergistic effects when combined with various antibiotics, including chloramphenicol, meropenem, and rifampicin, enhancing the efficacy against drug-resistant strains. K11 maintains high thermal stability and demonstrates effective function across a broad pH range, making it a valuable tool for antimicrobial research and therapeutic applications.
K11 is a stable antimicrobial peptide that exhibits significant activity against multidrug-resistant and extensively drug-resistant K. pneumoniae isolates, demonstrating a minimum inhibitory concentration (MIC) range of 8-512 μg/mL. This peptide not only inhibits bacterial biofilm formation but also displays synergistic effects when combined with various antibiotics, including chloramphenicol, meropenem, and rifampicin, enhancing the efficacy against drug-resistant strains. K11 maintains high thermal stability and demonstrates effective function across a broad pH range, making it a valuable tool for antimicrobial research and therapeutic applications.
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