Fig. 1 · Structure
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Kaempferol-7,4'-dimethyl ether
PTP1B Inhibitor
Kaempferol-7,4'-dimethyl ether is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 16.92 μM. It exhibits a significant inhibition rate of 46.1% at a concentration of 100 μM, and additionally, it has been shown to inhibit nitric oxide (NO) production. This compound is valuable for research applications focusing on metabolic disorders, obesity, and diabetes, where PTP1B plays a critical role in insulin signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 15486-33-6 |
| Applications | PTP1B Inhibitor |
| Formula | C17H14O6 |
| Molecular Weight | 314.29 |
| SMILES | O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=CC(O)=C13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.