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KAT6A/KAT7-IN-2

KAT6A/KAT7 Inhibitor

KAT6A/KAT7-IN-2 is a potent inhibitor of the histone acetyltransferases KAT6A and KAT7, exhibiting IC50 values of ≤ 1 nM for both targets. This compound effectively reduces acetylation at histone H3 lysine 14 (H3K14) and H3 lysine 23 (H3K23), thereby impacting gene expression regulation. Additionally, KAT6A/KAT7-IN-2 demonstrates significant antitumor activity, with an IC50 of ≤ 100 nM against the CAMA-1 cell line. It serves as a valuable tool for investigating the roles of KAT6A and KAT7 in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3092066-69-5
Applications	KAT6A/KAT7 Inhibitor
Formula	C₂₆H₂₈N₄O₆S
Molecular Weight	524.59
SMILES	O=C(NC)C1=CC(OC)=C(S(=O)(NC2=NOC3=C2CC4(C5=C3C=C(N6CCC6)C=C5)CC4)=O)C(OC)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.