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Fig. 1 · Structure
Cat. No.
A12284
CAS No.
4338-47-0
Formula
C15H17N5O5
Mol. Weight
347.33

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Kinetin riboside

PINK1 activator

Kinetin riboside is an activator of the Parkinson's Disease-associated PTEN-induced Putative Kinase 1 (PINK1), and acts independently from mitochondrial depolarization.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Caco-2 GI50 45.6 μM Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay [PMID: 18588281]
HT-29 GI50 60.2 μM Antitumor activity against human HT29 cells after 48 hrs by MTS assay [PMID: 18588281]
K562 GI50 3.3 μM Antitumor activity against human K562 cells after 48 hrs by MTS assay [PMID: 18588281]
MCF7 GI50 45.6 μM Antitumor activity against human MCF7 cells after 48 hrs by MTS assay [PMID: 18588281]
Platelet IC50 41.16 μM Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry [PMID: 25467153]
RD EC50 1.4 μM Antiviral activity against Enterovirus 71 infected in human RD cells assessed as cell viability after 3 days by MTS assay [PMID: 26854380]

Specifications

Manufacturer Adooq Bioscience
Actions Activator
CAS Number 4338-47-0
Applications PINK1 activator
Formula C15H17N5O5
Molecular Weight 347.33
Synonyms N6-Furfuryladenosine
SMILES
OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3NCC4=CC=CO4)O1)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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