Fig. 1 · Structure
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KJM429
Cat. No.
A68827
CAS
401907-57-1
rVR1 Modulator
KJM429 is a high-affinity ligand targeting the rat vanilloid receptor rTRPV1, exhibiting a Ki value of 30-63 nM. This compound functions as a competitive antagonist to inhibit TRPV1 activation by stimuli such as capsaicin, resiniferatoxin, and thermal signals, while switching to an agonist role under acidic conditions (pH < 5.5). KJM429 effectively modulates calcium influx associated with TRPV1 activation, making it a valuable tool for investigating the mechanisms underlying pain-related disorders, including postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis, and pruritus.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 401907-57-1 |
| Applications | rVR1 Modulator |
| Formula | C20H27N3O2S2 |
| Molecular Weight | 405.58 |
| Synonyms | MK-056 |
| SMILES | O=S(=O)(NC1=CC=C(C=C1)CNC(=S)NCC2=CC=C(C=C2)C(C)(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.