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KP-6

Catalog No.: A37102
Wnt/β-catenin Signal Inhibitor
KP-6 is a polypeptide that acts as a Wnt/β-catenin signaling pathway inhibitor. By inhibiting TGF-β, KP-6 disrupts critical fibrotic signaling pathways in vivo, effectively reducing renal tissue damage and fibrotic progression. This compound holds promise for research focused on chronic kidney disease (CKD) and other fibrosis-related disorders, making it a valuable tool for studying disease mechanisms and potential therapeutic interventions.
KP-6 2102414-23-1 Wnt/β-catenin Signal Inhibitor
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Size Price Stock Qty
1mg
$300.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKP-6 is a polypeptide that acts as a Wnt/β-catenin signaling pathway inhibitor. By inhibiting TGF-β, KP-6 disrupts critical fibrotic signaling pathways in vivo, effectively reducing renal tissue damage and fibrotic progression. This compound holds promise for research focused on chronic kidney disease (CKD) and other fibrosis-related disorders, making it a valuable tool for studying disease mechanisms and potential therapeutic interventions.
Product Information
Catalog NumA37102
FormulaC159H232N46O44
Molecular Weight3491.83
CAS Number2102414-23-1
SequenceGln-Pro-Val-Val-Thr-Leu-Tyr-His-Trp-Asp-Leu-Pro-Gln-Arg-Leu-Gln-Asp-Ala-Tyr-Gly-Gly-Trp-Ala-Asn-Arg-Ala-Leu-Ala-Asp-His
Sequence shorteningQPVVTLYHWDLPQRLQDAYGGWANRALADH
SMILESC([C@H](NC([C@H](CC1=CN=CN1)NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@H](CCC(N)=O)N)=O)CCC3)[C@@H](C)C)=O)C(C)C)=O)[C@@H](C)O)=O)CC(C)C)=O)=O)=O)C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(NCC(NCC(N[C@@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CN=CN8)C(O)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)C)=O)=O)=O)=O)=O)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCC4)CC(C)C)=O)CC(O)=O)=O)C=9C=%10C(NC9)=CC=CC%10
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Stem Cells/Wnt > Wnt
Stem Cells/Wnt > β-catenin