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KR-33028

NHE1 Inhibitor

KR-33028 is a selective inhibitor of the sodium/hydrogen exchanger 1 (NHE1). It effectively reduces hypoxia-induced necrosis and apoptosis in H9c2 cardiomyoblasts by inhibiting increases in cytoplasmic and mitochondrial calcium levels and preventing cytochrome c release. Furthermore, KR-33028 enhances cardiac contractility, decreases lactate dehydrogenase release, and boosts tissue levels of ATP, creatine phosphate, and glycogen. This compound is valuable for research into cancers such as cardioblastoma and cardiovascular conditions, including ischemic stroke.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	861218-37-3
Applications	NHE1 Inhibitor
Formula	C₁₁H₈N₄OS
Molecular Weight	244.27
SMILES	O=C(C1=CC2=C(C#N)C=CC=C2S1)NC(N)=N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.