KRAS Inhibitor-37 targets the KRAS protein, exhibiting high affinity with KDs of 0.004 nM, 0.041 nM, 0.019 nM, and 0.144 nM for KRAS wild type, G12D, G12C, and G12V variants, respectively, as determined by SPR binding assays. This compound demonstrates significant anti-proliferative activity, with IC50 values ranging from <2 nM to 14 nM across various cancer cell lines, including H358, SW620, and PANC08.13. KRAS Inhibitor-37 is a valuable tool for advancing research in cancer biology, particularly in studies focused on KRAS-driven malignancies.
KRAS Inhibitor-37 targets the KRAS protein, exhibiting high affinity with KDs of 0.004 nM, 0.041 nM, 0.019 nM, and 0.144 nM for KRAS wild type, G12D, G12C, and G12V variants, respectively, as determined by SPR binding assays. This compound demonstrates significant anti-proliferative activity, with IC50 values ranging from <2 nM to 14 nM across various cancer cell lines, including H358, SW620, and PANC08.13. KRAS Inhibitor-37 is a valuable tool for advancing research in cancer biology, particularly in studies focused on KRAS-driven malignancies.
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