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KRAS inhibitor-38

Catalog No.: A63745
KRAS Inhibitor
KRAS inhibitor-38 is a selective inhibitor targeting KRAS mutations, specifically KRAS G12C, KRAS G12D, and KRAS G12V. This compound effectively suppresses the activity of these mutant KRAS proteins in vivo, making it a valuable tool for research on KRAS-driven cancers. It is applicable in studies investigating the role of KRAS in tumorigenesis and potential therapeutic strategies for targeting KRAS mutations.
KRAS inhibitor-38 3059496-10-2 KRAS Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS inhibitor-38 is a selective inhibitor targeting KRAS mutations, specifically KRAS G12C, KRAS G12D, and KRAS G12V. This compound effectively suppresses the activity of these mutant KRAS proteins in vivo, making it a valuable tool for research on KRAS-driven cancers. It is applicable in studies investigating the role of KRAS in tumorigenesis and potential therapeutic strategies for targeting KRAS mutations.
Product Information
Catalog NumA63745
FormulaC53H68ClF2N9O8S
Molecular Weight1064.68
CAS Number3059496-10-2
SMILESCO[C@H](C1=[C@@](C=C(C=N1)N2CCOCC2)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C8C(CCCN83)=C7)=CS6)NC([C@@H](N(C(C9(CCN(CC9)C([C@@H](Cl)F)=O)F)=O)C)C(C)C)=O)=O)N5)=O)C)C
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Cell Cycle > Ras