Fig. 1 · Structure
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KRAS inhibitor-39
BI-0474 Intermediate
KRAS inhibitor-39 is an intermediate in the synthesis of BI-0474, a potent inhibitor of the KRASG12C mutation. This compound plays a crucial role in the development of targeted therapies for KRAS-driven cancers. Its application spans various research settings aimed at understanding the mechanisms of KRAS signaling and evaluating therapeutic strategies for malignancies associated with KRAS mutations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3034744-25-4 |
| Applications | BI-0474 Intermediate |
| Formula | C27H35N9OS |
| Molecular Weight | 533.69 |
| SMILES | N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(N5[C@@H](C)CN(C)CC5)=CC(N6CCNCC6)=C4)=NO3)CCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.