KRASG12D-IN-5 is a potent inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 11 nM. This compound demonstrates significant anticancer activity, displaying low cytotoxicity against various cell lines, including 10.37 μM for BxPC-3 (wild type), 0.76 μM for KRAS mutant AsPC-1 (G12D), and 0.3 μM for MIAPaCa-2 (G12C). KRASG12D-IN-5 is valuable for cancer research, particularly in the context of lung, pancreatic, and colorectal cancers.
KRASG12D-IN-5 is a potent inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 11 nM. This compound demonstrates significant anticancer activity, displaying low cytotoxicity against various cell lines, including 10.37 μM for BxPC-3 (wild type), 0.76 μM for KRAS mutant AsPC-1 (G12D), and 0.3 μM for MIAPaCa-2 (G12C). KRASG12D-IN-5 is valuable for cancer research, particularly in the context of lung, pancreatic, and colorectal cancers.
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