KRAS-IN-48 free base is a highly selective inhibitor targeting mutant KRAS, specifically KRAS G12D and KRAS G12V, with Kd values of 2.58 nM and 5.49 μM, respectively. This compound effectively reduces pERK expression in KRAS-mutant cells, exhibiting IC50 values of 1.1 μM and 1.51 μM for KRAS G12D and G12V mutations. KRAS-IN-48 free base serves as a valuable tool in cancer research, contributing to the understanding of KRAS-driven malignancies.
KRAS-IN-48 free base is a highly selective inhibitor targeting mutant KRAS, specifically KRAS G12D and KRAS G12V, with Kd values of 2.58 nM and 5.49 μM, respectively. This compound effectively reduces pERK expression in KRAS-mutant cells, exhibiting IC50 values of 1.1 μM and 1.51 μM for KRAS G12D and G12V mutations. KRAS-IN-48 free base serves as a valuable tool in cancer research, contributing to the understanding of KRAS-driven malignancies.
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