L-644698 is a highly selective agonist of the human recombinant prostaglandin D2 (PGD2) receptor (hDP), exhibiting Ki values of 0.9 nM for hDP and significantly higher values for other receptors (hEP2, hEP3, hEP4). This compound stimulates cyclic AMP production with an EC50 of 0.5 nM, making it a valuable tool for researching PGD2 receptor signaling pathways and their implications in various biological processes. Its specificity and potency render L-644698 an essential reagent for studies aimed at understanding the role of hDP in physiological and pathological states.
L-644698 is a highly selective agonist of the human recombinant prostaglandin D2 (PGD2) receptor (hDP), exhibiting Ki values of 0.9 nM for hDP and significantly higher values for other receptors (hEP2, hEP3, hEP4). This compound stimulates cyclic AMP production with an EC50 of 0.5 nM, making it a valuable tool for researching PGD2 receptor signaling pathways and their implications in various biological processes. Its specificity and potency render L-644698 an essential reagent for studies aimed at understanding the role of hDP in physiological and pathological states.
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