Fig. 1 · Structure
Documents & Downloads
L-656224
Cat. No.
A76463
CAS
102612-16-8
Leukotriene/5-lipoxygenase Inhibitor
L-656224 is a potent and selective inhibitor of leukotriene biosynthesis, acting primarily on 5-lipoxygenase. Demonstrating strong inhibitory activity in both intact rat and human leukocytes as well as CXBG mastocytoma cells (IC50 values ranging from 18 to 240 nM), it significantly impacts human and porcine leukocyte 5-lipoxygenase with an IC50 of 4 x 10^-7 M. This compound shows potential for research applications in asthma and the development of peripheral analgesic agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 102612-16-8 |
| Applications | Leukotriene/5-lipoxygenase Inhibitor |
| Formula | C20H21ClO3 |
| Molecular Weight | 344.83 |
| SMILES | ClC1=CC(CCC)=C(C2=C1OC(CC3=CC=C(C=C3)OC)=C2C)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.