L-736380 is a potent antagonist of the cholecystokinin B (CCK-B) receptor, exhibiting a high affinity with an IC50 of 0.054 nM for CCK-B and 400 nM for CCK-A. This compound effectively inhibits gastric acid secretion in anesthetized rats with an ID50 of 0.064 mg/kg. Additionally, L-736380 demonstrates significant activity in ex vivo binding assays of [125I]CCK-8S in BKTO mouse brain membranes, with an ED50 of 1.7 mg/kg. Its function as a CCK-B antagonist makes it a valuable tool for studies related to gastrointestinal physiology and neuropharmacology.
L-736380 is a potent antagonist of the cholecystokinin B (CCK-B) receptor, exhibiting a high affinity with an IC50 of 0.054 nM for CCK-B and 400 nM for CCK-A. This compound effectively inhibits gastric acid secretion in anesthetized rats with an ID50 of 0.064 mg/kg. Additionally, L-736380 demonstrates significant activity in ex vivo binding assays of [125I]CCK-8S in BKTO mouse brain membranes, with an ED50 of 1.7 mg/kg. Its function as a CCK-B antagonist makes it a valuable tool for studies related to gastrointestinal physiology and neuropharmacology.
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