L-741671 is a selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting significant brain permeability. It demonstrates binding affinities (Kis) of 64 nM, 0.03 nM, and 0.7 nM in rat, human, and ferret models, respectively. This compound is primarily utilized in research to investigate the role of NK-1 receptors in various neurological conditions and to explore potential therapeutic applications in pain and mood disorders.
L-741671 is a selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting significant brain permeability. It demonstrates binding affinities (Kis) of 64 nM, 0.03 nM, and 0.7 nM in rat, human, and ferret models, respectively. This compound is primarily utilized in research to investigate the role of NK-1 receptors in various neurological conditions and to explore potential therapeutic applications in pain and mood disorders.
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