Fig. 1 · Structure
Documents & Downloads
L-741671
NK Receptor Antagonist
L-741671 is a selective antagonist of the neurokinin-1 (NK-1) receptor, exhibiting significant brain permeability. It demonstrates binding affinities (Kis) of 64 nM, 0.03 nM, and 0.7 nM in rat, human, and ferret models, respectively. This compound is primarily utilized in research to investigate the role of NK-1 receptors in various neurological conditions and to explore potential therapeutic applications in pain and mood disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 187724-85-2 |
| Applications | NK Receptor Antagonist |
| Formula | C23H22F6N4O2 |
| Molecular Weight | 500.44 |
| SMILES | O=C1NNC(CN2[C@@H]([C@@H](CCC2)OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=CC=CC=C4)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.