Fig. 1 · Structure
Documents & Downloads
L 743310
hNK1 Antagonist
L 743310 is a selective non-peptide antagonist of the human neurokinin 1 (hNK1) receptor, exhibiting high affinity for both primate and cloned human receptors while displaying lower affinity for rodent NK1 receptors. This compound has demonstrated efficacy in inhibiting resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. Additionally, L 743310 exhibits a dose-dependent inhibitory effect on cisplatin-induced emesis, making it a valuable tool for research in neurokinin signaling and anti-emetic drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 187724-86-3 |
| Applications | hNK1 Antagonist |
| Formula | C30H33BrF6N4O2 |
| Molecular Weight | 675.50 |
| SMILES | C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.