Fig. 1 · Structure
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L-744832
Farnesyl Transferase Inhibitor
L-744832 is a potent farnesyl transferase inhibitor that effectively inhibits the farnesylation of H-Ras and N-Ras, with minimal impact on K-Ras. By targeting the oncogenic pathway, L-744832 enhances radiosensitivity through the restoration of TGF-β signaling via epigenetic reprogramming. This compound induces cell cycle arrest and apoptosis, making it suitable for combination therapy studies in Ras-driven tumors, including pancreatic cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 160141-09-3 |
| Applications | Farnesyl Transferase Inhibitor |
| Formula | C26H45N3O6S2 |
| Molecular Weight | 559.78 |
| SMILES | O=C(OC(C)C)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.