Fig. 1 · Structure
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L-745870 trihydrochloride
Dopamine D4 Receptor Antagonist
L-745870 trihydrochloride is a selective antagonist of the dopamine D4 receptor, characterized by a Ki value of 0.43 nM. This compound demonstrates reduced affinity for D2 and D3 receptors, with Ki values of 960 nM and 2300 nM, respectively. Additionally, L-745870 shows moderate interactions with 5-HT2 receptors, sigma sites, and α-adrenoceptors. It is primarily utilized in research focused on neuropharmacology and the modulation of dopaminergic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 866021-03-6 |
| Applications | Dopamine D4 Receptor Antagonist |
| Formula | C18H22Cl4N4 |
| Molecular Weight | 436.21 |
| SMILES | ClC(C=C1)=CC=C1N(CC2)CCN2CC3=CNC4=NC=CC=C43.Cl.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.