Fig. 1 · Structure
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L-745870
Dopamine D4 Receptor Antagonist
L-745870 is a highly selective antagonist of the dopamine D4 receptor, demonstrating a Ki of 0.43 nM. It exhibits limited affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, along with moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound is suitable for studies investigating the role of the dopamine D4 receptor in neurological disorders and provides insights into neuropharmacology-related research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 158985-00-3 |
| Applications | Dopamine D4 Receptor Antagonist |
| Formula | C18H19ClN4 |
| Molecular Weight | 326.82 |
| SMILES | ClC(C=C1)=CC=C1N(CC2)CCN2CC3=CNC4=NC=CC=C43 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.